The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion

• María Anguiano ,

  Contributed equally to this work with: María Anguiano, Xabier Morales

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

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• Xabier Morales ,

  Contributed equally to this work with: María Anguiano, Xabier Morales

  Roles Data curation, Formal analysis, Investigation, Visualization

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Carlos Castilla,

  Roles Investigation

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Alejandro Rodríguez Pena,

  Roles Investigation

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Cristina Ederra,

  Roles Investigation

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

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• Martín Martínez,

  Roles Formal analysis

  Affiliation Neuroimaging Laboratory, Division of Neurosciences, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  http://orcid.org/0000-0002-3053-7920

  ⨯
• Mikel Ariz,

  Roles Software

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Maider Esparza,

  Roles Investigation

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Hippolyte Amaveda,

  Roles Investigation

  Affiliation Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

  ⨯
• Mario Mora,

  Roles Investigation

  Affiliation Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

  ⨯
• Nieves Movilla,

  Roles Investigation

  Affiliation Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

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• José Manuel García Aznar,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain

  ⨯
• Iván Cortés-Domínguez,

  Roles Methodology, Writing – review & editing

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  ⨯
• Carlos Ortiz-de-Solorzano

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: codesolorzano@unav.es

  Affiliation IDISNA, Ciberonc and Solid Tumours and Biomarkers Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain

  http://orcid.org/0000-0001-8720-0205

  ⨯