SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation

Mingzhen Wang; Yu Wang; Yuehong Liu; Hailong Wang; Xiu Xin; Jiadai Li; Yao Hao; Lingling Han; Fang Yu; Congyi Zheng; Chao Shen

doi:10.1371/journal.pone.0219989

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Open Access

Peer-reviewed

Research Article

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation

Mingzhen Wang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Writing – original draft

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Yu Wang,

Roles Conceptualization, Data curation, Formal analysis

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Yuehong Liu,

Roles Investigation

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Hailong Wang,

Roles Methodology

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Xiu Xin,

Roles Software

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Jiadai Li,

Roles Resources

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Yao Hao,

Roles Resources

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Lingling Han,

Roles Software

Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
⨯
Fang Yu,

Roles Resources

Affiliation Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan, China
⨯
Congyi Zheng,

Roles Funding acquisition

Affiliations State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China, China Center for Type Culture Collection, Wuhan University, Wuhan, China
⨯
Chao Shen

Roles Funding acquisition, Writing – review & editing

* E-mail: shenchao@whu.edu.cn

Affiliations State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China, China Center for Type Culture Collection, Wuhan University, Wuhan, China

http://orcid.org/0000-0003-4687-0127

⨯

SPSB2 inhibits hepatitis C virus replication by targeting NS5A for ubiquitination and degradation

Mingzhen Wang,
Yu Wang,
Yuehong Liu,
Hailong Wang,
Xiu Xin,
Jiadai Li,
Yao Hao,
Lingling Han,
Fang Yu,
Congyi Zheng

Published: July 25, 2019
https://doi.org/10.1371/journal.pone.0219989

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Hepatitis C virus
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Immunoprecipitation
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Transfection
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Ubiquitination
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Viral replication
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Plasmid construction
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Protein domains
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Vector-borne diseases
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