The role of thrombin in the pathogenesis of diabetic neuropathy

Efrat Shavit-Stein; Ramona Aronovich; Constantin Sylantiev; Shany Guly Gofrit; Joab Chapman; Amir Dori

doi:10.1371/journal.pone.0219453

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Open Access

Peer-reviewed

Research Article

The role of thrombin in the pathogenesis of diabetic neuropathy

Efrat Shavit-Stein ,

Contributed equally to this work with: Efrat Shavit-Stein, Ramona Aronovich

Roles Conceptualization, Formal analysis, Writing – original draft

* E-mail: efrat.shavit.stein@gmail.com

Affiliations Department of Neurology, Sheba Medical Center, Tel HaShomer, Israel, Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel
⨯
Ramona Aronovich ,

Contributed equally to this work with: Efrat Shavit-Stein, Ramona Aronovich

Roles Data curation, Investigation, Writing – original draft

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Constantin Sylantiev,

Roles Investigation, Methodology

Affiliation Department of Neurology, Sheba Medical Center, Tel HaShomer, Israel
⨯
Shany Guly Gofrit,

Roles Writing – original draft

Affiliation Department of Neurology, Sheba Medical Center, Tel HaShomer, Israel

http://orcid.org/0000-0001-6104-606X

⨯
Joab Chapman ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliations Department of Neurology, Sheba Medical Center, Tel HaShomer, Israel, Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Robert and Martha Harden Chair in Mental and Neurological Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Amir Dori

Roles Investigation, Methodology

¶‡ These authors also contributed equally to this work.

Affiliations Department of Neurology, Sheba Medical Center, Tel HaShomer, Israel, Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel, Department of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Talpiot medical leadership program, Sheba Medical Center, Tel HaShomer, Israel
⨯

The role of thrombin in the pathogenesis of diabetic neuropathy

Efrat Shavit-Stein,
Ramona Aronovich,
Constantin Sylantiev,
Shany Guly Gofrit,
Joab Chapman,
Amir Dori

Published: July 5, 2019
https://doi.org/10.1371/journal.pone.0219453

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Diabetes mellitus
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Thrombin
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Neuropathy
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Sciatic nerves
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