Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment

Erin L. Britt; Sarina Raman; Kendall Leek; Casey H. Sheehy; Sung W. Kim; Hisashi Harada

doi:10.1371/journal.pone.0219398

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Open Access

Peer-reviewed

Research Article

Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment

Erin L. Britt ,

Contributed equally to this work with: Erin L. Britt, Sarina Raman

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Sarina Raman ,

Contributed equally to this work with: Erin L. Britt, Sarina Raman

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Kendall Leek,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Casey H. Sheehy,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Sung W. Kim,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Hisashi Harada

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hharada@vcu.edu

Affiliation Philips Institute for Oral Health Research, School of Dentistry, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America

http://orcid.org/0000-0001-5993-1289

⨯

Combination of fenretinide and ABT-263 induces apoptosis through NOXA for head and neck squamous cell carcinoma treatment

Erin L. Britt,
Sarina Raman,
Kendall Leek,
Casey H. Sheehy,
Sung W. Kim,
Hisashi Harada

Published: July 5, 2019
https://doi.org/10.1371/journal.pone.0219398

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Apoptosis
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Cell death
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Immunoprecipitation
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Head and neck squamous cell carcinoma
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Cancer treatment
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Cell staining
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