Evaluation of eluforsen, a novel RNA oligonucleotide for restoration of CFTR function in in vitro and murine models of p.Phe508del cystic fibrosis

• Wouter Beumer ,

  Contributed equally to this work with: Wouter Beumer, Jim Swildens

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: wbeumer@proqr.com

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

  http://orcid.org/0000-0003-0291-516X

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• Jim Swildens ,

  Contributed equally to this work with: Wouter Beumer, Jim Swildens

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Teresinha Leal,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision

  Affiliation Université Catholique de Louvain, Louvain Centre for Toxicology and Applied Pharmacology, Brussels, Belgium

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• Sabrina Noel,

  Roles Investigation, Resources

  Affiliation Université Catholique de Louvain, Louvain Centre for Toxicology and Applied Pharmacology, Brussels, Belgium

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• Herma Anthonijsz,

  Roles Investigation, Resources

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Geert van der Horst,

  Roles Investigation, Resources

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Hester Kuiperij-Boersma,

  Roles Investigation, Resources

  Current address: LabPON Laboratorium Pathologie Oost-Nederland, Hengelo, The Netherlands

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Marko Potman,

  Roles Investigation, Resources

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Charlotte van Putten,

  Roles Investigation, Resources

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Patricia Biasutto,

  Roles Investigation, Resources

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Gerard Platenburg,

  Roles Conceptualization, Funding acquisition

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Hugo de Jonge,

  Roles Conceptualization, Methodology, Validation

  Affiliation Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands

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• Noreen Henig,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Current address: Breath Therapeutics Inc., Menlo Park, CA, United States of America

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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• Tita Ritsema

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation ProQR Therapeutics, Leiden, The Netherlands

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