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Open Access
Peer-reviewed
Research Article
Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study
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Yehuda Z. Cohen,
Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Allison L. Butler,
Roles Investigation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Katrina Millard,
Roles Investigation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Maggi Witmer-Pack,
Roles Data curation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Rebeka Levin,
Roles Data curation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Cecilia Unson-O’Brien,
Roles Investigation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Roshni Patel,
Roles Investigation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Irina Shimeliovich,
Roles Supervision
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Julio C. C. Lorenzi,
Roles Investigation
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Jill Horowitz,
Roles Project administration
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Stephen R. Walsh,
Roles Investigation
Affiliation Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
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Shu Lin,
Roles Investigation
Affiliation Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America
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Joshua A. Weiner,
Roles Supervision
Affiliation Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America
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Anna Tse,
Roles Investigation
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Alicia Sato,
Roles Formal analysis
Affiliation Vaccine and Infectious Disease Division and Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Chelsey Bennett,
Roles Formal analysis
Affiliation Vaccine and Infectious Disease Division and Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Bryan Mayer,
Roles Formal analysis
Affiliation Vaccine and Infectious Disease Division and Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Kelly E. Seaton,
Roles Formal analysis, Investigation, Supervision
Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
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Nicole L. Yates,
Roles Formal analysis, Investigation, Supervision
Affiliation Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America
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Lindsey R. Baden,
Roles Investigation, Supervision
Affiliation Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, United States of America
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Allan C. deCamp,
Roles Formal analysis
Affiliation Vaccine and Infectious Disease Division and Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Margaret E. Ackerman,
Roles Supervision
Affiliation Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, United States of America
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Michael S. Seaman,
Roles Supervision
Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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Georgia D. Tomaras,
Roles Supervision
Affiliations Duke Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
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Michel C. Nussenzweig,
Roles Conceptualization, Supervision
Affiliations Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
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Marina Caskey
Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing
* E-mail: mcaskey@rockefeller.edu
Affiliation Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America
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Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study
- Yehuda Z. Cohen,
- Allison L. Butler,
- Katrina Millard,
- Maggi Witmer-Pack,
- Rebeka Levin,
- Cecilia Unson-O’Brien,
- Roshni Patel,
- Irina Shimeliovich,
- Julio C. C. Lorenzi,
- Jill Horowitz
- Published: August 8, 2019
- https://doi.org/10.1371/journal.pone.0219142