NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome

• Wout J. Weuring,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  http://orcid.org/0000-0002-7439-5653

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• Sakshi Singh,

  Roles Data curation, Methodology, Resources

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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• Linda Volkers,

  Roles Data curation, Investigation, Methodology, Resources

  Affiliation Department of Cardiology, Laboratory of Experimental Cardiology, University Medical Centre Leiden, Leiden, the Netherlands

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• Martin B. Rook,

  Roles Data curation, Methodology

  Affiliation Department of Medical Physiology, University Medical Centre Utrecht, Utrecht, the Netherlands

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• Ruben H. van ‘t Slot,

  Roles Data curation, Methodology, Resources

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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• Marjolein Bosma,

  Roles Data curation

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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• Marco Inserra,

  Roles Data curation

  Affiliation Centre for Pain Research & School of Pharmacy, University of Queensland, Brisbane, Australia

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• Irina Vetter,

  Roles Data curation, Investigation, Methodology

  Affiliation Centre for Pain Research & School of Pharmacy, University of Queensland, Brisbane, Australia

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• Nanda M. Verhoeven-Duif,

  Roles Data curation, Investigation

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

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• Kees P. J. Braun,

  Roles Conceptualization, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Neurology, University Medical Centre Utrecht, Utrecht, the Netherlands

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• Mirko Rivara,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Food and Drug Department, University of Parma, Parma, Italy

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• Bobby P. C. Koeleman

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  * E-mail: b.p.c.koeleman@umcutrecht.nl

  Affiliation Department of Genetics, Center for Molecular Medicine, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands

  http://orcid.org/0000-0001-7749-182X

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