Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling

Qiangqiang Shao; Tao Yang; Huai Huang; Tanushree Majumder; Bhakti Ajit Khot; Mohammad Masoudian Khouzani; Farrah Alarmanazi; Yasmin K. Gore; Guofa Liu

doi:10.1371/journal.pone.0218811

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Open Access

Peer-reviewed

Research Article

Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling

Qiangqiang Shao,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Tao Yang,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Huai Huang,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Tanushree Majumder,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Bhakti Ajit Khot,

Roles Data curation, Visualization

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Mohammad Masoudian Khouzani,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Farrah Alarmanazi,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Yasmin K. Gore,

Roles Investigation

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America
⨯
Guofa Liu

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Guofa.Liu@utoledo.edu

Affiliation Department of Biological Sciences, University of Toledo, Toledo, OH, United States of America

http://orcid.org/0000-0003-1464-1493

⨯

Disease-associated mutations in human TUBB3 disturb netrin repulsive signaling

Qiangqiang Shao,
Tao Yang,
Huai Huang,
Tanushree Majumder,
Bhakti Ajit Khot,
Mohammad Masoudian Khouzani,
Farrah Alarmanazi,
Yasmin K. Gore,
Guofa Liu

Published: June 21, 2019
https://doi.org/10.1371/journal.pone.0218811

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Neurons
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Microtubules
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Axons
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Axon guidance
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Transfection
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Chemoattractant axon guidance
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Microtubule dynamics
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Missense mutation
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