Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease

Jonathan R. Lindner; Todd Belcik; Michael Widlansky; Leanne M. Harmann; Matthew S. Karafin; Nancy J. Wandersee; Maneka Puligandla; Donna Neuberg; Joel Linden; Joshua J. Field

doi:10.1371/journal.pone.0218783

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Open Access

Peer-reviewed

Research Article

Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease

Jonathan R. Lindner,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Knight Cardiovascular Institute, Oregon Health Sciences University, Portland, OR, United States of America
⨯
Todd Belcik,

Roles Conceptualization, Formal analysis, Methodology

Affiliation Knight Cardiovascular Institute, Oregon Health Sciences University, Portland, OR, United States of America
⨯
Michael Widlansky,

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America
⨯
Leanne M. Harmann,

Roles Investigation, Writing – review & editing

Affiliation Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America
⨯
Matthew S. Karafin,

Roles Data curation, Writing – review & editing

Affiliation Medical Sciences Institute, Versiti Wisconsin, Milwaukee, WI, United States of America
⨯
Nancy J. Wandersee,

Roles Investigation, Writing – review & editing

Affiliation Medical Sciences Institute, Versiti Wisconsin, Milwaukee, WI, United States of America
⨯
Maneka Puligandla,

Roles Formal analysis

Affiliation Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, United States of America
⨯
Donna Neuberg,

Roles Formal analysis

Affiliation Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, United States of America
⨯
Joel Linden,

Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

Affiliations Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, CA, United States of America
⨯
Joshua J. Field

Roles Conceptualization, Investigation, Methodology, Writing – original draft

* E-mail: JField@Versiti.org

Affiliations Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States of America, Medical Sciences Institute, Versiti Wisconsin, Milwaukee, WI, United States of America

http://orcid.org/0000-0001-8148-055X

⨯

Contrast-enhanced ultrasound detects changes in microvascular blood flow in adults with sickle cell disease

Jonathan R. Lindner,
Todd Belcik,
Michael Widlansky,
Leanne M. Harmann,
Matthew S. Karafin,
Nancy J. Wandersee,
Maneka Puligandla,
Donna Neuberg,
Joel Linden,
Joshua J. Field

Published: July 5, 2019
https://doi.org/10.1371/journal.pone.0218783

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Blood flow
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Ultrasound imaging
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Pain
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