A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy

• Georgios Kaissis ,

  Contributed equally to this work with: Georgios Kaissis, Sebastian Ziegelmayer, Fabian Lohöfer

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany

  http://orcid.org/0000-0001-8382-8062

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• Sebastian Ziegelmayer ,

  Contributed equally to this work with: Georgios Kaissis, Sebastian Ziegelmayer, Fabian Lohöfer

  Roles Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliation Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany

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• Fabian Lohöfer ,

  Contributed equally to this work with: Georgios Kaissis, Sebastian Ziegelmayer, Fabian Lohöfer

  Roles Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany

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• Katja Steiger,

  Roles Formal analysis, Methodology, Visualization

  Affiliation Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany

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• Hana Algül,

  Roles Project administration, Supervision

  Affiliation Department of Internal Medicine II, School of Medicine, Technical University of Munich, Munich, Germany

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• Alexander Muckenhuber,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany

  http://orcid.org/0000-0002-0414-1797

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• Hsi-Yu Yen,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany

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• Ernst Rummeny,

  Roles Project administration, Supervision

  Affiliation Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany

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• Helmut Friess,

  Roles Project administration, Supervision

  Affiliation Department of Surgery, School of Medicine, Technical University of Munich, Munich, Germany

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• Roland Schmid,

  Roles Project administration, Supervision

  Affiliation Department of Internal Medicine II, School of Medicine, Technical University of Munich, Munich, Germany

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• Wilko Weichert,

  Roles Funding acquisition, Project administration, Supervision

  Affiliation Department of Pathology, School of Medicine, Technical University of Munich, Munich, Germany

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• Jens T. Siveke,

  Roles Conceptualization, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Division of Solid Tumor Translational Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany

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• Rickmer Braren

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: rbraren@tum.de

  Affiliation Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, Munich, Germany

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