Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation

• Jinwoo Kim ,

  Contributed equally to this work with: Jinwoo Kim, Diane M. Bogdan, Matthew W. Elmes

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft

  Affiliations Department of Chemistry, Stony Brook University, Stony Brook, New York, United States of America, Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, United States of America

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• Diane M. Bogdan ,

  Contributed equally to this work with: Jinwoo Kim, Diane M. Bogdan, Matthew W. Elmes

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Department of Anesthesiology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Matthew W. Elmes ,

  Contributed equally to this work with: Jinwoo Kim, Diane M. Bogdan, Matthew W. Elmes

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Monaf Awwa,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

  Affiliation Department of Chemistry, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Su Yan,

  Roles Data curation, Investigation, Methodology, Validation

  Affiliation Department of Chemistry, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Joyce Che,

  Roles Data curation, Investigation

  Affiliation Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Garam Lee,

  Roles Data curation, Investigation

  Affiliation Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Dale G. Deutsch,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Robert C. Rizzo,

  Roles Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing

  Affiliations Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, United States of America, Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Martin Kaczocha ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: iwao.ojima@stonybrook.edu (IO); martin.kaczocha@stonybrook.edu (MK)

  ¶‡ These authors also contributed equally to this work

  Affiliations Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, United States of America, Department of Anesthesiology, Stony Brook University, Stony Brook, New York, United States of America, Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, United States of America

  ⨯
• Iwao Ojima

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: iwao.ojima@stonybrook.edu (IO); martin.kaczocha@stonybrook.edu (MK)

  ¶‡ These authors also contributed equally to this work

  Affiliations Department of Chemistry, Stony Brook University, Stony Brook, New York, United States of America, Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, United States of America

  http://orcid.org/0000-0002-3628-1161

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