Increased compensatory kidney workload results in cellular damage in a short time porcine model of mixed acidemia – Is acidemia a ‘first hit’ in acute kidney injury?

• Martin Russ ,

  Contributed equally to this work with: Martin Russ, Sascha Ott

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: martin.russ@charite.de

  Affiliation Department of Anesthesiology and Operative Intensive Care Medicine, Campus Virchow-Klinikum and Campus Charité Mitte, Charité–Universitätsmedizin Berlin, Berlin, Germany

  http://orcid.org/0000-0003-4719-2452

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• Sascha Ott ,

  Contributed equally to this work with: Martin Russ, Sascha Ott

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Experimental Medicine, Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Berlin, Germany

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• Janis R. Bedarf,

  Roles Data curation, Formal analysis, Visualization, Writing – review & editing

  Affiliations Department of Neurology, University of Bonn, Bonn, Germany, German Centre for Neurodegenerative Disease Research (DZNE), Bonn, Germany

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• Michael Kirschfink,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Institute for Clinical Immunology, University Hospital Heidelberg, Heidelberg, Germany

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• Bernhard Hiebl,

  Roles Supervision, Validation, Writing – review & editing

  Affiliation Institute for Animal Hygiene, Animal Welfare and Farm Animal Behaviour and Virtual Center for Replacement–Complementary Methods to Animal Testing, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany

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• Juliane K. Unger

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Experimental Medicine, Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Berlin, Germany

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