E46K mutant α-synuclein is more degradation resistant and exhibits greater toxic effects than wild-type α-synuclein in Drosophila models of Parkinson's disease

• Ryusuke Sakai,

  Roles Data curation, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Mari Suzuki,

  Roles Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan

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• Morio Ueyama,

  Roles Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Toshihide Takeuchi,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Eiko N. Minakawa,

  Roles Writing – review & editing

  Affiliation Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

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• Hideki Hayakawa,

  Roles Resources

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Kousuke Baba,

  Roles Resources

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Hideki Mochizuki,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

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• Yoshitaka Nagai

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: nagai@neurother.med.osaka-u.ac.jp

  Affiliations Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

  http://orcid.org/0000-0003-1037-3129

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