Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity

Takafumi Yotsumoto; Naomi Morozumi; Ryuichi Nakamura; Toshimasa Jindo; Mayumi Furuya; Yasuyuki Abe; Tomonari Nishimura; Hiroaki Maeda; Hiroyuki Ogasawara; Yoshiharu Minamitake; Kenji Kangawa

doi:10.1371/journal.pone.0218229

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Open Access

Peer-reviewed

Research Article

Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity

Takafumi Yotsumoto ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: yotsumoto.takafumi.ur@daiichisankyo.co.jp

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan

http://orcid.org/0000-0003-1940-4577

⨯
Naomi Morozumi,

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan
⨯
Ryuichi Nakamura,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Toshimasa Jindo,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Mayumi Furuya,

Roles Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan
⨯
Yasuyuki Abe,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Tomonari Nishimura,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Hiroaki Maeda,

Roles Project administration, Resources, Supervision

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Hiroyuki Ogasawara,

Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Writing – review & editing

Affiliations Asubio Pharma Co., Ltd., Kobe, Japan, Daiichi Sankyo Co., Ltd., Tokyo, Japan
⨯
Yoshiharu Minamitake,

Roles Supervision

Affiliation Asubio Pharma Co., Ltd., Kobe, Japan
⨯
Kenji Kangawa

Roles Conceptualization, Visualization, Writing – review & editing

Affiliation National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
⨯

Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity

Takafumi Yotsumoto,
Naomi Morozumi,
Ryuichi Nakamura,
Toshimasa Jindo,
Mayumi Furuya,
Yasuyuki Abe,
Tomonari Nishimura,
Hiroaki Maeda,
Hiroyuki Ogasawara,
Yoshiharu Minamitake

Published: September 11, 2019
https://doi.org/10.1371/journal.pone.0218229
See the preprint

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