Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes

Fouzeyyah Alsaeedi; Rachel Wilson; Charlotte Candlish; Ibrahim Ibrahim; Alistair C. Leitch; Tarek M. Abdelghany; Colin Wilson; Lyle Armstrong; Matthew C. Wright

doi:10.1371/journal.pone.0218135

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Open Access

Peer-reviewed

Research Article

Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes

Fouzeyyah Alsaeedi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, Faculty of Medical Sciences, Taif University, Taif, KSA
⨯
Rachel Wilson,

Roles Investigation, Methodology

Affiliation Institute Human Genetics, Newcastle University, Newcastle Upon Tyne, United Kingdom
⨯
Charlotte Candlish,

Roles Investigation, Methodology

Affiliation Institute Human Genetics, Newcastle University, Newcastle Upon Tyne, United Kingdom
⨯
Ibrahim Ibrahim,

Roles Investigation, Methodology

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, Freeman Hospital, Newcastle Upon Tyne, United Kingdom
⨯
Alistair C. Leitch,

Roles Investigation, Methodology

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom
⨯
Tarek M. Abdelghany,

Roles Investigation, Methodology

Affiliations Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt
⨯
Colin Wilson,

Roles Methodology, Project administration

Affiliation Freeman Hospital, Newcastle Upon Tyne, United Kingdom
⨯
Lyle Armstrong,

Roles Methodology, Project administration

Affiliation Institute Human Genetics, Newcastle University, Newcastle Upon Tyne, United Kingdom
⨯
Matthew C. Wright

Roles Conceptualization, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: M.C.Wright@ncl.ac.uk

Affiliation Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom

http://orcid.org/0000-0003-3167-6743

⨯

Expression of serine/threonine protein kinase SGK1F promotes an hepatoblast state in stem cells directed to differentiate into hepatocytes

Fouzeyyah Alsaeedi,
Rachel Wilson,
Charlotte Candlish,
Ibrahim Ibrahim,
Alistair C. Leitch,
Tarek M. Abdelghany,
Colin Wilson,
Lyle Armstrong,
Matthew C. Wright

Published: June 26, 2019
https://doi.org/10.1371/journal.pone.0218135

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Cell differentiation
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Hepatocytes
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Endoderm
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Induced pluripotent stem cells
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Protein expression
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Wnt signaling cascade
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Fibroblast growth factor
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