Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing

• James S. Floyd ,

  Contributed equally to this work with: James S. Floyd, Katarzyna M. Bloch, Jennifer A. Brody

  Roles Data curation, Funding acquisition, Investigation, Project administration, Validation, Writing – review & editing

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Katarzyna M. Bloch ,

  Contributed equally to this work with: James S. Floyd, Katarzyna M. Bloch, Jennifer A. Brody

  Roles Formal analysis, Investigation, Project administration, Validation, Writing – original draft

  Affiliation MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Jennifer A. Brody ,

  Contributed equally to this work with: James S. Floyd, Katarzyna M. Bloch, Jennifer A. Brody

  Roles Data curation, Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – review & editing

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Cyrielle Maroteau,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Writing – review & editing

  Affiliation Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom

  ⨯
• Moneeza K. Siddiqui,

  Roles Data curation, Investigation, Project administration, Software, Validation

  Affiliation Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom

  ⨯
• Richard Gregory,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Supervision

  Affiliation Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Daniel F. Carr,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Mariam Molokhia,

  Roles Data curation, Funding acquisition, Project administration, Supervision, Validation

  Affiliation School of Population Health and Environmental Sciences, London, United Kingdom

  ⨯
• Xiaoming Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

  Affiliation Human Genetics Center, University of Texas Health Science Center, Houston, United States of America

  http://orcid.org/0000-0001-8285-5528

  ⨯
• Joshua C. Bis,

  Roles Data curation, Investigation, Project administration, Resources, Supervision, Visualization

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Ammar Ahmed,

  Roles Data curation, Project administration, Validation, Visualization, Writing – review & editing

  Affiliation Medical School, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Xuan Liu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Pär Hallberg,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Software, Writing – review & editing

  Affiliation Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala University Hospital, Uppsala, Sweden

  ⨯
• Qun-Ying Yue,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Medical Products Agency, Uppsala, Sweden

  ⨯
• Patrik K. E. Magnusson,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Diane Brisson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – review & editing

  Affiliation Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Université de Montréal Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada

  ⨯
• Kerri L. Wiggins,

  Roles Data curation, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  http://orcid.org/0000-0003-2749-1279

  ⨯
• Alanna C. Morrison,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Etienne Khoury,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Software, Supervision, Writing – review & editing

  Affiliation Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Université de Montréal Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada

  ⨯
• Paul McKeigue,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Usher Institute of Population Health Sciences and Informatics, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom

  ⨯
• Bruno H. Stricker,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands

  ⨯
• Maryse Lapeyre-Mestre,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Software, Supervision, Validation, Writing – review & editing

  Affiliation Paul Sabatier University - Toulouse III, UPS Toulouse, Laboratoire de Pharmacologie Medicale et Clinique, Toulouse, France

  http://orcid.org/0000-0002-5494-5873

  ⨯
• Susan R. Heckbert,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Software

  Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

  ⨯
• Arlene M. Gallagher,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Clinical Practice Research Datalink (CPRD) Medicines and Healthcare Products Regulatory Agency, London, United Kingdom

  ⨯
• Hector Chinoy,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation

  Affiliation Rheumatology Department, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom

  ⨯
• Richard A. Gibbs,

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America

  ⨯
• Emmanuelle Bondon-Guitton,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

  Affiliation Centre Hospitalier Universitaire de Toulouse, CHU Toulouse, Centre de Pharmacovigilance, Toulouse, France

  ⨯
• Russell Tracy,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

  Affiliation Departments of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont, United States of America

  ⨯
• Eric Boerwinkle,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

  ⨯
• Daniel Gaudet,

  Roles Conceptualization, Data curation, Investigation, Methodology, Software, Writing – review & editing

  Affiliation Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Université de Montréal Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada

  ⨯
• Anita Conforti,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliation U.O. Farmacologia, Policlinico "Gb Rossi", Verona, Italy

  ⨯
• Tjeerd van Staa,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Software, Supervision, Writing – review & editing

  Affiliation Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom

  ⨯
• Colleen M. Sitlani,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Kenneth M. Rice,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Software, Supervision, Writing – review & editing

  Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

  ⨯
• Anke-Hilse Maitland-van der Zee,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Respiratory Medicine/Pediatric Respiratory Medicine, AMC, Amsterdam, the Netherlands

  ⨯
• Mia Wadelius,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Medical School, University of Liverpool, Liverpool, United Kingdom

  http://orcid.org/0000-0002-6368-2622

  ⨯
• Andrew P. Morris,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft

  Affiliation Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Munir Pirmohamed,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

  ⨯
• Colin A. N. Palmer,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

  Affiliation Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom

  ⨯
• Bruce M. Psaty ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Department of Medicine, University of Washington, Seattle, Washington, United States of America

  ⨯
• Ana Alfirevic ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Ana.Alfirevic@liverpool.ac.uk

  ¶‡ These authors also contributed equally to this work.

  Affiliation MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom

  http://orcid.org/0000-0002-2801-9817

  ⨯
•  [ ... ],
• on behalf of the PREDICTION-ADR Consortium and EUDRAGENE

  ¶¶ The complete membership of the author groups can be found in the Acknowledgments

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