Enhancement of binding avidity by bivalent binding enables PrP^Sc-specific detection by anti-PrP monoclonal antibody 132

• Akio Suzuki,

  Roles Investigation, Writing – original draft

  Affiliation Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita-ku, Sapporo, Japan

  ⨯
• Takeshi Yamasaki,

  Roles Investigation

  Affiliation Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita-ku, Sapporo, Japan

  ⨯
• Rie Hasebe,

  Roles Investigation

  Affiliation Biomedical Animal Research Laboratory, Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo, Japan

  ⨯
• Motohiro Horiuchi

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: horiuchi@vetmed.hokudai.ac.jp

  Affiliations Laboratory of Veterinary Hygiene, Faculty of Veterinary Medicine, Graduate School of Infectious Diseases, Hokkaido University, Kita-ku, Sapporo, Japan, Global Station for Zoonosis Control. Global Institute for Collaborative Research and Education, Hokkaido University, Kita-ku, Sapporo, Japan

  http://orcid.org/0000-0003-1785-4355

  ⨯