A simple immunohistochemical bio-profile incorporating Bcl2 curbs those cases of invasive breast carcinoma for which an Oncotype Dx characterization is needed

Claudio Ceccarelli; Antonio De Leo; Pasquale Chieco; Claudio Zamagni; Alice Zamagni; Daniela Rubino; Mario Taffurelli; Donatella Santini

doi:10.1371/journal.pone.0217937

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Peer-reviewed

Research Article

A simple immunohistochemical bio-profile incorporating Bcl2 curbs those cases of invasive breast carcinoma for which an Oncotype Dx characterization is needed

Claudio Ceccarelli ,

Contributed equally to this work with: Claudio Ceccarelli, Antonio De Leo

Roles Conceptualization, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft

* E-mail: claudio.ceccarelli@unibo.it

Affiliation Department of Experimental, Diagnostic and Specialty Medicine–DIMES, St.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

http://orcid.org/0000-0003-0743-2087

⨯
Antonio De Leo ,

Contributed equally to this work with: Claudio Ceccarelli, Antonio De Leo

Roles Conceptualization, Investigation, Visualization, Writing – original draft

Affiliation Department of Experimental, Diagnostic and Specialty Medicine–DIMES, St.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
⨯
Pasquale Chieco,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Unified Centre for Biomedical Applied Research–CRBA, St.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
⨯
Claudio Zamagni,

Roles Investigation

Affiliation Breast Medical Oncology Unit, Department of Hematology and Oncology, St.Orsola-Malpighi Hospital, Bologna, Italy
⨯
Alice Zamagni,

Roles Investigation

Affiliation Radiation Oncology Unit, S.Orsola-Malpighi Hospital, Bologna, Italy
⨯
Daniela Rubino,

Roles Investigation

Affiliation Breast Medical Oncology Unit, Department of Hematology and Oncology, St.Orsola-Malpighi Hospital, Bologna, Italy
⨯
Mario Taffurelli,

Roles Investigation

Affiliation Department of Medical and Surgical Sciences–DIMEC, St.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
⨯
Donatella Santini

Roles Supervision, Writing – review & editing

Affiliation Surgical Pathology Unit, Department of Diagnostic and Prevention Medicine, St.Orsola-Malpighi Hospital, Bologna, Italy
⨯

A simple immunohistochemical bio-profile incorporating Bcl2 curbs those cases of invasive breast carcinoma for which an Oncotype Dx characterization is needed

Claudio Ceccarelli,
Antonio De Leo,
Pasquale Chieco,
Claudio Zamagni,
Alice Zamagni,
Daniela Rubino,
Mario Taffurelli,
Donatella Santini

Published: June 3, 2019
https://doi.org/10.1371/journal.pone.0217937

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Cancer risk factors
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Immunohistochemistry techniques
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Breast cancer
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Immunohistochemical analysis
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