Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie; Fabio Zuccotto; David A. Robinson; David W. Gray; Ian H. Gilbert; Manu De Rycker

doi:10.1371/journal.pone.0217828

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Peer-reviewed

Research Article

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Fabio Zuccotto,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
David A. Robinson,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
David W. Gray,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Ian H. Gilbert ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: I.H.Gilbert@dundee.ac.uk (IHG); M.DeRycker@dundee.ac.uk (MDR)

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom
⨯
Manu De Rycker

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

* E-mail: I.H.Gilbert@dundee.ac.uk (IHG); M.DeRycker@dundee.ac.uk (MDR)

Affiliation Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, United Kingdom

http://orcid.org/0000-0002-3171-3519

⨯

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase

Leah S. Torrie,
Fabio Zuccotto,
David A. Robinson,
David W. Gray,
Ian H. Gilbert,
Manu De Rycker

Published: May 31, 2019
https://doi.org/10.1371/journal.pone.0217828

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Library screening
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Sequence motif analysis
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Trypanosoma brucei gambiense
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High throughput screening
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Sequence alignment
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Kinetoplastids
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Parasitic diseases
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