Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity

Norman Fultang; Abhinav Illendula; Brian Chen; Chun Wu; Subash Jonnalagadda; Nathan Baird; Zachary Klase; Bela Peethambaran

doi:10.1371/journal.pone.0217789

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Peer-reviewed

Research Article

Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity

Norman Fultang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biology, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Abhinav Illendula,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Biology, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Brian Chen,

Roles Formal analysis, Software

Affiliation Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, United States of America
⨯
Chun Wu,

Roles Data curation, Formal analysis, Software, Supervision

Affiliation Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, United States of America
⨯
Subash Jonnalagadda,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Department of Chemistry & Biochemistry, Rowan University, Glassboro, New Jersey, United States of America
⨯
Nathan Baird,

Roles Data curation

Affiliation Department of Chemistry & Biochemistry, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Zachary Klase,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Biology, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Bela Peethambaran

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: b.peethambaran@usciences.edu

Affiliation Department of Biology, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0002-2719-3928

⨯

Strictinin, a novel ROR1-inhibitor, represses triple negative breast cancer survival and migration via modulation of PI3K/AKT/GSK3ß activity

Norman Fultang,
Abhinav Illendula,
Brian Chen,
Chun Wu,
Subash Jonnalagadda,
Nathan Baird,
Zachary Klase,
Bela Peethambaran

Published: May 31, 2019
https://doi.org/10.1371/journal.pone.0217789

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