Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

Spela Kos; Alessandra Lopes; Veronique Preat; Maja Cemazar; Ursa Lampreht Tratar; Bernard Ucakar; Kevin Vanvarenberg; Gregor Sersa; Gaelle Vandermeulen

doi:10.1371/journal.pone.0217762

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Open Access

Peer-reviewed

Research Article

Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

Spela Kos ,

Contributed equally to this work with: Spela Kos, Alessandra Lopes

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
⨯
Alessandra Lopes ,

Contributed equally to this work with: Spela Kos, Alessandra Lopes

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Veronique Preat ,

Roles Conceptualization, Supervision, Validation, Writing – review & editing

* E-mail: gsersa@onko-i.si (GS); veronique.preat@uclouvain.be (VP)

Affiliation Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Maja Cemazar,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliations Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia, Faculty of Health Sciences, University of Primorska, Izola, Slovenia
⨯
Ursa Lampreht Tratar,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
⨯
Bernard Ucakar,

Roles Investigation, Methodology

Affiliation Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Kevin Vanvarenberg,

Roles Formal analysis, Investigation, Methodology

Affiliation Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
⨯
Gregor Sersa ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: gsersa@onko-i.si (GS); veronique.preat@uclouvain.be (VP)

Affiliations Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia

http://orcid.org/0000-0002-7641-5670

⨯
Gaelle Vandermeulen

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, Belgium
⨯

Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma

Spela Kos,
Alessandra Lopes,
Veronique Preat,
Maja Cemazar,
Ursa Lampreht Tratar,
Bernard Ucakar,
Kevin Vanvarenberg,
Gregor Sersa,
Gaelle Vandermeulen

Published: May 31, 2019
https://doi.org/10.1371/journal.pone.0217762

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