Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Naoki Tanimine; Sharon K. Germana; Martin Fan; Keli Hippen; Bruce R. Blazar; James F. Markmann; Laurence A. Turka; Bhavana Priyadharshini

doi:10.1371/journal.pone.0217761

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Open Access

Peer-reviewed

Research Article

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Naoki Tanimine,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America

http://orcid.org/0000-0003-2744-9097

⨯
Sharon K. Germana,

Roles Resources

Affiliation Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-8769-3991

⨯
Martin Fan,

Roles Methodology

Affiliation Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Keli Hippen,

Roles Formal analysis, Validation

Affiliation Department of Pediatrics, Division of Hematology/Oncology and Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota, United States of America
⨯
Bruce R. Blazar,

Roles Methodology, Resources

Affiliation Department of Pediatrics, Division of Hematology/Oncology and Blood and Marrow Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota, United States of America
⨯
James F. Markmann,

Roles Resources

Affiliation Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Laurence A. Turka,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

Affiliations Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Rheos Medicines, Boston, Massachusetts, United States of America
⨯
Bhavana Priyadharshini

Roles Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: bpriyadharshini@rheosrx.com

Affiliations Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Rheos Medicines, Boston, Massachusetts, United States of America
⨯

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Naoki Tanimine,
Sharon K. Germana,
Martin Fan,
Keli Hippen,
Bruce R. Blazar,
James F. Markmann,
Laurence A. Turka,
Bhavana Priyadharshini

Published: June 6, 2019
https://doi.org/10.1371/journal.pone.0217761

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Glycolysis
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T cells
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