Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

• Khalid Almahmoud ,

  Contributed equally to this work with: Khalid Almahmoud, Andrew Abboud

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Graduate Medical Education, Department of Surgery, Methodist Dallas Health System, Dallas, TX, United States of America

  http://orcid.org/0000-0001-9716-3778

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• Andrew Abboud ,

  Contributed equally to this work with: Khalid Almahmoud, Andrew Abboud

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Rami A. Namas,

  Roles Investigation, Methodology, Resources, Software

  Affiliations Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Ruben Zamora,

  Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliations Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

  http://orcid.org/0000-0003-3882-9087

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• Jason Sperry,

  Roles Investigation, Resources

  Affiliation Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Andrew B. Peitzman,

  Roles Investigation, Resources

  Affiliation Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Michael S. Truitt,

  Roles Investigation

  Affiliation Department of Graduate Medical Education, Department of Surgery, Methodist Dallas Health System, Dallas, TX, United States of America

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• Greg E. Gaski,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, IN, United States of America

  http://orcid.org/0000-0002-2795-4029

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• Todd O. McKinley,

  Roles Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Orthopedic Surgery, Indiana University School of Medicine, Indianapolis, IN, United States of America

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• Timothy R. Billiar,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Yoram Vodovotz

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: vodovotzy@upmc.edu

  Affiliations Department of Surgery, Division of Trauma & Critical Care Surgery, University of Pittsburgh, Pittsburgh, PA, United States of America, Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States of America

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