Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats

Rui Zhao; Qing Wang; Xin-Xin Hu; Tong-Ying Nie; Xin-Yi Yang; Cong-Ran Li; Xi Lu; Xiukun Wang; Jian-Dong Jiang; Jing Pang; Xue-Fu You

doi:10.1371/journal.pone.0217573

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Open Access

Peer-reviewed

Research Article

Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats

Rui Zhao,

Roles Investigation, Writing – original draft

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Qing Wang,

Roles Investigation

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xin-Xin Hu,

Roles Investigation

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Tong-Ying Nie,

Roles Investigation

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xin-Yi Yang,

Roles Data curation

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Cong-Ran Li,

Roles Writing – review & editing

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xi Lu,

Roles Writing – review & editing

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Xiukun Wang,

Roles Data curation

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jian-Dong Jiang,

Roles Conceptualization

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jing Pang ,

Contributed equally to this work with: Jing Pang, Xue-Fu You

Roles Conceptualization, Writing – review & editing

* E-mail: pangjing.pangjing@163.com (JP); xuefuyou@imb.pumc.edu.cn (XFY)

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

http://orcid.org/0000-0002-0538-0327

⨯
Xue-Fu You

Contributed equally to this work with: Jing Pang, Xue-Fu You

Roles Conceptualization

* E-mail: pangjing.pangjing@163.com (JP); xuefuyou@imb.pumc.edu.cn (XFY)

Affiliation Beijing Key Laboratory of Antimicrobial Agents and Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Microdialysis combined with liquid chromatography-tandem mass spectrometry for the quantitation of gemifloxacin and its application to a muscle penetration study in healthy and MRSA-infected rats

Rui Zhao,
Qing Wang,
Xin-Xin Hu,
Tong-Ying Nie,
Xin-Yi Yang,
Cong-Ran Li,
Xi Lu,
Xiukun Wang,
Jian-Dong Jiang,
Jing Pang

Published: June 6, 2019
https://doi.org/10.1371/journal.pone.0217573

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