Challenges and caveats of a multi-center retrospective radiomics study: an example of early treatment response assessment for NSCLC patients using FDG-PET/CT radiomics

• Janna E. van Timmeren ,

  Contributed equally to this work with: Janna E. van Timmeren, Sara Carvalho

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: j.vantimmeren@maastrichtuniversity.nl

  Affiliations The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands, Department of Radiation Oncology (MAASTRO clinic), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

  http://orcid.org/0000-0002-8166-6853

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• Sara Carvalho ,

  Contributed equally to this work with: Janna E. van Timmeren, Sara Carvalho

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO clinic), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Ralph T. H. Leijenaar,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Esther G. C. Troost,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliations OncoRay–National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Cal Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden–Rossendorf, Dresden, Germany, Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, Helmholtz-Zentrum Dresden–Rossendorf, Institute of Radiooncology—OncoRay, Dresden, Germany, German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany, National Center for Tumor Diseases (NCT) Partner Site Dresden, Dresden, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, Helmholtz Association / Helmholtz-Zentrum Dresden–Rossendorf (HZDR), Dresden, Germany

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• Wouter van Elmpt,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO clinic), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Dirk de Ruysscher,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Department of Radiation Oncology (MAASTRO clinic), GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Jean-Pierre Muratet,

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Centre Jean Bernard, Clinique Victor Hugo, Le Mans, France

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• Fabrice Denis,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Centre Jean Bernard, Clinique Victor Hugo, Le Mans, France

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• Tanja Schimek-Jasch,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Department for Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany

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• Ursula Nestle,

  Roles Conceptualization, Data curation, Writing – review & editing

  Affiliation Department for Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany

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• Arthur Jochems,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Henry C. Woodruff,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

  http://orcid.org/0000-0001-7911-5123

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• Cary Oberije,

  Roles Conceptualization, Methodology, Validation, Writing – review & editing

  Affiliation The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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• Philippe Lambin

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation The D-Lab: Decision Support for Precision Medicine, GROW—School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Maastricht, The Netherlands

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