Parameter estimation and mathematical modeling for the quantitative description of therapy failure due to drug resistance in gastrointestinal stromal tumor metastasis to the liver

• Patricio Cumsille ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: pcumsille@ubiobio.cl

  Affiliations Group of Investigation in Tumor Angiogenesis (GIANT), Group of Research and Innovation in Vascular Health (GRIVAS Health), Basic Sciences Department, Universidad del Bío-Bío, Chillán, Chile, Centre for Biotechnology and Bioengineering (CeBiB), Santiago, Chile

  http://orcid.org/0000-0003-1067-129X

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• Matías Godoy,

  Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliation Centre for Biotechnology and Bioengineering (CeBiB), Santiago, Chile

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• Ziomara P. Gerdtzen,

  Roles Supervision, Visualization, Writing – review & editing

  Affiliations Centre for Biotechnology and Bioengineering (CeBiB), Santiago, Chile, Department of Chemical Engineering, Biotechnology and Materials, University of Chile, Santiago, Chile

  http://orcid.org/0000-0002-7486-8537

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• Carlos Conca

  Roles Funding acquisition, Supervision

  Affiliations Centre for Biotechnology and Bioengineering (CeBiB), Santiago, Chile, Department of Mathematical Engineering (DIM) and Center for Mathematical Modeling (CMM), University of Chile, (UMI CNRS 2807), Santiago, Chile

  http://orcid.org/0000-0003-3891-0846

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