Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies

Petra Majerova; Alena Michalicova; Martin Cente; Jozef Hanes; Jozef Vegh; Agnes Kittel; Nina Kosikova; Viera Cigankova; Sandra Mihaljevic; Santosh Jadhav; Andrej Kovac

doi:10.1371/journal.pone.0217216

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Open Access

Peer-reviewed

Research Article

Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies

Petra Majerova,

Roles Investigation, Writing – original draft

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic
⨯
Alena Michalicova,

Roles Investigation

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic
⨯
Martin Cente,

Roles Data curation

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic
⨯
Jozef Hanes,

Roles Investigation

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic
⨯
Jozef Vegh,

Roles Investigation

Affiliation Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic
⨯
Agnes Kittel,

Roles Data curation

Affiliation Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary

http://orcid.org/0000-0002-6888-7731

⨯
Nina Kosikova,

Roles Investigation

Affiliation Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic
⨯
Viera Cigankova,

Roles Data curation, Methodology

Affiliation Department of Anatomy, Histology and Physiology, The University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic
⨯
Sandra Mihaljevic,

Roles Methodology

Affiliation Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic
⨯
Santosh Jadhav,

Roles Methodology, Writing – original draft

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic
⨯
Andrej Kovac

Roles Investigation, Supervision, Writing – original draft

* E-mail: andrej.kovac@savba.sk

Affiliations Institute of Neuroimmunology, Slovak Academy of Sciences, AD Centre, Bratislava, Slovak Republic, AXON Neuroscience R&D Services SE, Bratislava, Slovak Republic, Department of Pharmacology and Toxicology, The University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic

http://orcid.org/0000-0002-3223-8705

⨯

Trafficking of immune cells across the blood-brain barrier is modulated by neurofibrillary pathology in tauopathies

Petra Majerova,
Alena Michalicova,
Martin Cente,
Jozef Hanes,
Jozef Vegh,
Agnes Kittel,
Nina Kosikova,
Viera Cigankova,
Sandra Mihaljevic,
Santosh Jadhav

Published: May 23, 2019
https://doi.org/10.1371/journal.pone.0217216

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Genetically modified animals
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T cells
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Brainstem
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Endothelial cells
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Tau protein
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Adhesion molecules
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Blood-brain barrier
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