Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Saki Miyake; Hitoshi Higuchi; Yuka Honda-Wakasugi; Maki Fujimoto; Hotaka Kawai; Hitoshi Nagatsuka; Shigeru Maeda; Takuya Miyawaki

doi:10.1371/journal.pone.0217209

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Open Access

Peer-reviewed

Research Article

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Saki Miyake,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hitoshi Higuchi,

Roles Conceptualization, Supervision

Affiliation Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan

http://orcid.org/0000-0002-8600-7793

⨯
Yuka Honda-Wakasugi,

Roles Investigation

Affiliation Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Maki Fujimoto,

Roles Investigation

Affiliation Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hotaka Kawai,

Roles Investigation

Affiliation Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Hitoshi Nagatsuka,

Roles Supervision

Affiliation Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shigeru Maeda,

Roles Formal analysis

Affiliation Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan
⨯
Takuya Miyawaki

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: miyawaki@md.okayama-u.ac.jp

Affiliation Department of Dental Anesthesiology and Special Care Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

http://orcid.org/0000-0002-6378-2623

⨯

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Saki Miyake,
Hitoshi Higuchi,
Yuka Honda-Wakasugi,
Maki Fujimoto,
Hotaka Kawai,
Hitoshi Nagatsuka,
Shigeru Maeda,
Takuya Miyawaki

Published: May 24, 2019
https://doi.org/10.1371/journal.pone.0217209

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