Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Willemijn S. M. E. Theelen; Thomas Kuilman; Katja Schulze; Wei Zou; Oscar Krijgsman; Dennis D. G. C. Peters; Sten Cornelissen; Kim Monkhorst; Pranamee Sarma; Teiko Sumiyoshi; Lukas C. Amler; Stefan M. Willems; Johannes L. G. Blaauwgeers; Carel J. M. van Noesel; Daniel S. Peeper; Michel M. van den Heuvel; Marcin Kowanetz

doi:10.1371/journal.pone.0216864

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Peer-reviewed

Research Article

Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Willemijn S. M. E. Theelen ,

Contributed equally to this work with: Willemijn S. M. E. Theelen, Thomas Kuilman

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft

* E-mail: w.theelen@nki.nl

Affiliation Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Thomas Kuilman ,

Contributed equally to this work with: Willemijn S. M. E. Theelen, Thomas Kuilman

Roles Formal analysis, Writing – original draft

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

http://orcid.org/0000-0001-6724-6767

⨯
Katja Schulze,

Roles Data curation, Formal analysis, Resources, Writing – original draft

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America
⨯
Wei Zou,

Roles Formal analysis

Affiliation Biostatistics, Genentech Inc., South San Francisco, United States of America
⨯
Oscar Krijgsman,

Roles Formal analysis

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Dennis D. G. C. Peters,

Roles Project administration, Resources, Writing – original draft

Affiliation Core Facility Molecular Pathology & Biobanking, Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Sten Cornelissen,

Roles Project administration, Resources, Writing – review & editing

Affiliation Core Facility Molecular Pathology & Biobanking, Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Kim Monkhorst,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Division of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands
⨯
Pranamee Sarma,

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America
⨯
Teiko Sumiyoshi,

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America
⨯
Lukas C. Amler,

Roles Project administration, Resources

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America
⨯
Stefan M. Willems,

Roles Resources

Affiliation Department of Pathology, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Johannes L. G. Blaauwgeers,

Roles Resources

Affiliation Department of Pathology, OLVG, Amsterdam, The Netherlands
⨯
Carel J. M. van Noesel,

Roles Resources

Affiliation Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Daniel S. Peeper ,

Roles Resources

¶‡ These authors also contributed equally to this work.

Affiliation Division of Molecular Oncology & Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
⨯
Michel M. van den Heuvel ,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Department of Pulmonology, Radboud University Medical Center, Nijmegen, The Netherlands
⨯
[ ... ],
Marcin Kowanetz

Roles Conceptualization, Supervision, Writing – review & editing

¶‡ These authors also contributed equally to this work.

Affiliation Oncology Biomarker Development, Genentech Inc., South San Francisco, United States of America
⨯
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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer

Willemijn S. M. E. Theelen,
Thomas Kuilman,
Katja Schulze,
Wei Zou,
Oscar Krijgsman,
Dennis D. G. C. Peters,
Sten Cornelissen,
Kim Monkhorst,
Pranamee Sarma,
Teiko Sumiyoshi

Published: May 24, 2019
https://doi.org/10.1371/journal.pone.0216864

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Non-small cell lung cancer
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Gene expression
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Cancers and neoplasms
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Protein expression
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Malignant tumors
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Immunohistochemistry techniques
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Cytotoxic T cells
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Immune response
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