Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: Randomized crossover clinical trial in healthy volunteers

• Sergio Barroso,

  Roles Data curation, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliations Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, Internal Medicine Department—Hospital Clínic of Barcelona (HCB), Barcelona, Spain, Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain, Pompeu Fabra University, Barcelona, Spain, Autonomous University of Barcelona, Barcelona, Spain

  http://orcid.org/0000-0001-7504-4794

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• Constanza Morén ,

  Roles Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cmoren1@clinic.ub.es (CM); garrabou@clinic.ub.es (GG)

  Affiliations Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, Internal Medicine Department—Hospital Clínic of Barcelona (HCB), Barcelona, Spain, Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain

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• Àlex González-Segura,

  Roles Investigation, Methodology

  Affiliations Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, Internal Medicine Department—Hospital Clínic of Barcelona (HCB), Barcelona, Spain, Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain

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• Neus Riba,

  Roles Investigation, Methodology, Project administration, Supervision

  Affiliation Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain

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• Joan A. Arnaiz,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain

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• Marcela Manriquez,

  Roles Methodology

  Affiliation Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain

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• Gemina Santana,

  Roles Methodology

  Affiliation Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain

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• José L. Blanco,

  Roles Investigation, Methodology, Project administration

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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• María Larousse,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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• Montse Loncà,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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• Elisa de Lazzari,

  Roles Formal analysis

  Affiliation Department of Statistics, University of Barcelona, Barcelona, Spain

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• Jaume Llopis,

  Roles Formal analysis

  Affiliation Department of Statistics, University of Barcelona, Barcelona, Spain

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• Josep Mallolas,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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• Oscar Miró,

  Roles Funding acquisition, Investigation, Methodology, Resources, Visualization

  Affiliation Emergency Department, HCB, Barcelona, Spain

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• Xavier Carné,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Phase I Unit, Clinical Pharmacology Department, HCB, Barcelona, Spain

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• Jose M. Gatell,

  Roles Investigation, Methodology, Project administration, Resources

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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• Glòria Garrabou ,

  Contributed equally to this work with: Glòria Garrabou, Esteban Martínez

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: cmoren1@clinic.ub.es (CM); garrabou@clinic.ub.es (GG)

  Affiliations Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain, Internal Medicine Department—Hospital Clínic of Barcelona (HCB), Barcelona, Spain, Biomedical Research Networking Centres of Rare Diseases CIBERER (ISCIII), Barcelona, Spain

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•  [ ... ],
• Esteban Martínez

  Contributed equally to this work with: Glòria Garrabou, Esteban Martínez

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Infectious Diseases Department, HCB, Barcelona, Spain

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