Loss of BRUCE reduces cellular energy level and induces autophagy by driving activation of the AMPK-ULK1 autophagic initiating axis

• Lixiao Che,

  Roles Formal analysis, Methodology, Project administration, Validation, Writing – review & editing

  Affiliation Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Xingyuan Yang,

  Roles Formal analysis, Investigation, Project administration

  Affiliation Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Chunmin Ge,

  Roles Methodology

  Affiliation Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Salim S. El-Amouri,

  Roles Investigation

  Affiliation Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

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• Qi-En Wang,

  Roles Methodology, Resources

  Affiliation Department of Radiology, Ohio State University, Columbus, Ohio, United States of America

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• Dao Pan,

  Roles Supervision, Writing – review & editing

  Affiliations Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America

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• Thomas J. Herzog,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Division of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, Ohio, United States of America, University of Cincinnati Cancer Institute, Cincinnati, Ohio, United States of America

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• Chunying Du

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: ducg@ucmail.uc.edu

  Affiliations Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, University of Cincinnati Cancer Institute, Cincinnati, Ohio, United States of America

  http://orcid.org/0000-0002-2850-7781

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