Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering

• Monique R. Heitmeier ,

  Contributed equally to this work with: Monique R. Heitmeier, Richard C. Hresko

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America

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• Richard C. Hresko ,

  Contributed equally to this work with: Monique R. Heitmeier, Richard C. Hresko

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America

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• Rachel L. Edwards,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America

  http://orcid.org/0000-0002-7928-7440

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• Michael J. Prinsen,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation High Throughput Screening Center, Washington University School of Medicine, St Louis, MO, United States of America

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• Ma Xenia G. Ilagan,

  Roles Formal analysis, Resources, Supervision, Validation, Writing – review & editing

  Affiliation High Throughput Screening Center, Washington University School of Medicine, St Louis, MO, United States of America

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• Audrey R. Odom John,

  Roles Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  Affiliations Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, United States of America

  http://orcid.org/0000-0001-8395-8537

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• Paul W. Hruz

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: hruz_p@wustl.edu

  Affiliations Department of Pediatrics, Washington University School of Medicine, St Louis, MO, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, United States of America

  http://orcid.org/0000-0002-1478-3355

  ⨯