Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model

• Yasufumi Saito,

  Roles Data curation, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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• Takao Hinoi ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: thinoi@hiroshima-u.ac.jp

  Affiliations Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan, Department of Clinical and Molecular Genetics, Hiroshima University Hospital, Hiroshima, Japan, Department of Surgery, Division of Molecular Oncology, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan

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• Tomohiro Adachi,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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• Masashi Miguchi,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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• Hiroaki Niitsu,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan, Vanderbilt University Medical Center, GI medicine, Nashville, Tennessee, United States of America

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• Masatoshi Kochi,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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• Haruki Sada,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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• Yusuke Sotomaru,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliation Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan

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• Naoya Sakamoto,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan

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• Kazuhiro Sentani,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan

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• Naohide Oue,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan

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• Wataru Yasui,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Japan

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• Hirotaka Tashiro,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan, Department of Surgery, Division of Molecular Oncology, Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan

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• Hideki Ohdan

  Roles Supervision, Writing – review & editing

  Affiliation Department of Gastroenterological and Transplant Surgery, Division of Medicine, Biomedical Sciences Major, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan

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