An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

Dominique Detaille; Philippe Pasdois; Audrey Sémont; Pierre Dos Santos; Philippe Diolez

doi:10.1371/journal.pone.0216385

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Peer-reviewed

Research Article

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

Dominique Detaille,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations IHU Liryc, L’institut de rythmologie et modélisation cardiaque, Fondation Bordeaux Université, Pessac-Bordeaux, France, Université de Bordeaux, Bordeaux, France, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France
⨯
Philippe Pasdois,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

Affiliations IHU Liryc, L’institut de rythmologie et modélisation cardiaque, Fondation Bordeaux Université, Pessac-Bordeaux, France, Université de Bordeaux, Bordeaux, France, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France
⨯
Audrey Sémont,

Roles Data curation, Formal analysis, Methodology

Affiliations IHU Liryc, L’institut de rythmologie et modélisation cardiaque, Fondation Bordeaux Université, Pessac-Bordeaux, France, Université de Bordeaux, Bordeaux, France, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France
⨯
Pierre Dos Santos,

Roles Funding acquisition, Resources, Validation, Writing – review & editing

Affiliations IHU Liryc, L’institut de rythmologie et modélisation cardiaque, Fondation Bordeaux Université, Pessac-Bordeaux, France, Université de Bordeaux, Bordeaux, France, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France, Centre Hospitalo-Universitaire de Bordeaux (CHU), Pôle Cardio-thoracique, Pessac, France
⨯
Philippe Diolez

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: philippe.diolez@u-bordeaux.fr

Affiliations IHU Liryc, L’institut de rythmologie et modélisation cardiaque, Fondation Bordeaux Université, Pessac-Bordeaux, France, Université de Bordeaux, Bordeaux, France, INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, Bordeaux, France

http://orcid.org/0000-0002-7548-2070

⨯

An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals

Dominique Detaille,
Philippe Pasdois,
Audrey Sémont,
Pierre Dos Santos,
Philippe Diolez

Published: May 2, 2019
https://doi.org/10.1371/journal.pone.0216385

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Heart
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Reperfusion
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Oxidative phosphorylation
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Reactive oxygen species
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