Asparaginase combined with discontinuous dexamethasone improves antileukemic efficacy without increasing osteonecrosis in preclinical models

• Seth E. Karol ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: Seth.Karol@stjude.org

  Affiliation Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

  http://orcid.org/0000-0001-8113-8180

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• Laura J. Janke,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• John C. Panetta,

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Laura B. Ramsey,

  Roles Methodology, Writing – review & editing

  Current address: Division of Clinical Pharmacology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Xiangjun Cai,

  Roles Data curation, Methodology, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Monique A. Payton,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• David A. Jenkins,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• William E. Evans,

  Roles Data curation, Supervision, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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• Mary V. Relling

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft

  Affiliation Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

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