Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration

• Sithandiwe E. Mazibuko-Mbeje ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Writing – original draft, Writing – review & editing

  * E-mail: sithandiwe.mazibuko@mrc.ac.za.

  Affiliations Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa, Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

  http://orcid.org/0000-0002-0946-8027

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• Phiwayinkosi V. Dludla,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa, Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

  http://orcid.org/0000-0001-5965-3610

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• Rabia Johnson,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa, Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

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• Elizabeth Joubert,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Plant Bioactives Group, Post-Harvest and Agro-Processing Technologies, Agricultural Research Council, Infruitec-Nietvoorbij, Stellenbosch, South Africa, Department of Food Science, Stellenbosch University, Stellenbosch, South Africa

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• Johan Louw,

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

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• Khanyisani Ziqubu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

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• Luca Tiano,

  Roles Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

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• Sonia Silvestri,

  Roles Conceptualization, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

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• Patrick Orlando,

  Roles Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy

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• Andy R. Opoku,

  Roles Conceptualization, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

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• Christo J. F. Muller

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa, Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa, Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

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