Dynamic modelling of an ACADS genotype in fatty acid oxidation – Application of cellular models for the analysis of common genetic variants

• Kerstin Matejka ,

  Contributed equally to this work with: Kerstin Matejka, Ferdinand Stückler

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Chair of Nutritional Medicine, Else Kröner-Fresenius-Center for Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, ZIEL-Research Center for Nutrition and Food Sciences, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technische Universität München, Freising-Weihenstephan, Germany

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• Ferdinand Stückler ,

  Contributed equally to this work with: Kerstin Matejka, Ferdinand Stückler

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany

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• Michael Salomon,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation SIRION Biotech GmbH, Martinsried, Germany

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• Regina Ensenauer,

  Roles Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliations Research Center, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität München, München, Germany, Experimental Pediatrics and Metabolism, Department of General Pediatrics, Neonatology and Pediatric Cardiology, University Children’s Hospital, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, Institute of Child Nutrition, Max Rubner-Institut, Karlsruhe, Germany

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• Eva Reischl,

  Roles Resources, Writing – review & editing

  Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Lena Hoerburger,

  Roles Investigation

  Affiliation Paediatric Nutritional Medicine, Else Kröner-Fresenius-Centre for Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany

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• Harald Grallert,

  Roles Resources, Writing – review & editing

  Affiliations German Center for Diabetes Research (DZD), Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technische Universität München, Freising-Weihenstephan, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Gabi Kastenmüller,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliation Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

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• Annette Peters,

  Roles Resources, Writing – review & editing

  Affiliations German Center for Diabetes Research (DZD), Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, German Research Center for Cardiovascular Disease (DZHK-Munich partner site), Neuherberg, Germany

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• Hannelore Daniel,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations ZIEL-Research Center for Nutrition and Food Sciences, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, Chair of Physiology of Human Nutrition, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany

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• Jan Krumsiek,

  Roles Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliations Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Institute for Computational Biomedicine, Englander Institute for Precision Medicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, United States of America

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• Fabian J. Theis ,

  Roles Funding acquisition, Methodology, Software, Supervision, Writing – review & editing

  * E-mail: fabian.theis@helmholtz-zentrum.de (FJT); helmut.laumen@tum.de (HL)

  Affiliations Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Department of Mathematical Science, Technische Universität München, Garching, Germany

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• Hans Hauner,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Chair of Nutritional Medicine, Else Kröner-Fresenius-Center for Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, ZIEL-Research Center for Nutrition and Food Sciences, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technische Universität München, Freising-Weihenstephan, Germany, Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, München, Germany

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• Helmut Laumen

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fabian.theis@helmholtz-zentrum.de (FJT); helmut.laumen@tum.de (HL)

  Affiliations Chair of Nutritional Medicine, Else Kröner-Fresenius-Center for Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, ZIEL-Research Center for Nutrition and Food Sciences, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, German Center for Diabetes Research (DZD), Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany, Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Technische Universität München, Freising-Weihenstephan, Germany, Paediatric Nutritional Medicine, Else Kröner-Fresenius-Centre for Nutritional Medicine, TUM School of Life Sciences Weihenstephan, Technische Universität München, Freising-Weihenstephan, Germany, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany, Research Unit Protein Science, Helmholtz Zentrum München, Neuherberg, Germany

  http://orcid.org/0000-0002-5885-5242

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