Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects

Terri L. Ryan; Antonio G. Pantelias; Georgia I. Terzoudi; Gabriel E. Pantelias; Adayabalam S. Balajee

doi:10.1371/journal.pone.0216081

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Open Access

Peer-reviewed

Research Article

Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects

Terri L. Ryan,

Roles Data curation, Formal analysis, Investigation

Affiliation Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Center/Training site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, Tennessee, United States of America
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Antonio G. Pantelias,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Health Physics, Radiobiology & Cytogenetics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, Ag. Paraskevi, Athens, Greece
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Georgia I. Terzoudi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Health Physics, Radiobiology & Cytogenetics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, Ag. Paraskevi, Athens, Greece
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Gabriel E. Pantelias,

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Writing – review & editing

Affiliation Health Physics, Radiobiology & Cytogenetics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research “Demokritos”, Ag. Paraskevi, Athens, Greece
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Adayabalam S. Balajee

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Adayabalam.balajee@orau.org

Affiliation Cytogenetic Biodosimetry Laboratory, Radiation Emergency Assistance Center/Training site, Oak Ridge Institute for Science and Education, Oak Ridge Associated Universities, Oak Ridge, Tennessee, United States of America

http://orcid.org/0000-0001-9957-1513

⨯

Use of human lymphocyte G0 PCCs to detect intra- and inter-chromosomal aberrations for early radiation biodosimetry and retrospective assessment of radiation-induced effects

Terri L. Ryan,
Antonio G. Pantelias,
Georgia I. Terzoudi,
Gabriel E. Pantelias,
Adayabalam S. Balajee

Published: May 6, 2019
https://doi.org/10.1371/journal.pone.0216081

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Lymphocytes
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Chromosomal translocations
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Gamma rays
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Dicentric chromosomes
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Chromosomes
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Fluorescent in situ hybridization
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Cell fusion
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Chromosomal aberrations
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