Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells

Damodara Reddy Vaddi; Lin Piao; Shakil A. Khan; Ning Wang; Nanduri R. Prabhakar; Jayasri Nanduri

doi:10.1371/journal.pone.0215905

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Peer-reviewed

Research Article

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells

Damodara Reddy Vaddi,

Roles Data curation, Formal analysis, Methodology

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0002-4441-0859

⨯
Lin Piao,

Roles Data curation, Formal analysis, Methodology

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America
⨯
Shakil A. Khan,

Roles Data curation, Formal analysis, Methodology

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America
⨯
Ning Wang,

Roles Data curation, Formal analysis, Methodology

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America
⨯
Nanduri R. Prabhakar,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jayasri Nanduri

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: jnanduri@uchicago.edu

Affiliation Institute for Integrative Physiology, Center for Systems Biology of O2 Sensing, Biological Sciences Division, The University of Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0003-3984-7447

⨯

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells

Damodara Reddy Vaddi,
Lin Piao,
Shakil A. Khan,
Ning Wang,
Nanduri R. Prabhakar,
Jayasri Nanduri

Published: April 24, 2019
https://doi.org/10.1371/journal.pone.0215905

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Hypoxia
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Membrane trafficking
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Membrane proteins
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Protein expression
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Reactive oxygen species
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Protein transport
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Serine proteases
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Cell proliferation
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