Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli

• Jennifer Konczal,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Drug Discovery Program, CRUK Beatson Institute, Glasgow, United Kingdom

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• Justin Bower,

  Roles Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Drug Discovery Program, CRUK Beatson Institute, Glasgow, United Kingdom

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• Christopher H. Gray

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: c.gray@beatson.gla.ac.uk

  Affiliation Drug Discovery Program, CRUK Beatson Institute, Glasgow, United Kingdom

  http://orcid.org/0000-0002-9895-0682

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