Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs

• Daniel L. Clemens ,

  Contributed equally to this work with: Daniel L. Clemens, Bai-Yu Lee

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  http://orcid.org/0000-0003-0421-7306

  ⨯
• Bai-Yu Lee ,

  Contributed equally to this work with: Daniel L. Clemens, Bai-Yu Lee

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  ⨯
• Aleidy Silva,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California, United States of America

  http://orcid.org/0000-0002-2426-281X

  ⨯
• Barbara Jane Dillon,

  Roles Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  ⨯
• Saša Masleša-Galić,

  Roles Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  ⨯
• Susana Nava,

  Roles Investigation

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  ⨯
• Xianting Ding,

  Roles Formal analysis

  Affiliation Med-X Research Institute, School of Biomedical Engineering, Shianghai Jiao Tong University, Shanghai, China

  http://orcid.org/0000-0002-1549-3499

  ⨯
• Chih-Ming Ho,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, California, United States of America, Department of Bioengineering, University of California, Los Angeles, California, United States of America

  http://orcid.org/0000-0001-7369-5446

  ⨯
• Marcus A. Horwitz

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: MHorwitz@mednet.ucla.edu

  Affiliation Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, California, United States of America

  ⨯