Computational modeling of pancreatic cancer patients receiving FOLFIRINOX and gemcitabine-based therapies identifies optimum intervention strategies

• Kimiyo N. Yamamoto,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, United States of America, Departments of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan

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• Akira Nakamura,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States of America

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• Lin L. Liu,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America

  http://orcid.org/0000-0002-9883-7962

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• Shayna Stein,

  Roles Writing – original draft, Writing – review & editing

  Affiliations Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America

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• Angela C. Tramontano,

  Roles Data curation

  Affiliation Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, United States of America

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• Uri Kartoun,

  Roles Data curation

  Affiliation Center for Systems Biology, Center for Assessment Technology & Continuous Health (CATCH), Massachusetts General Hospital, Boston, MA, United States of America

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• Tetsunosuke Shimizu,

  Roles Data curation

  Affiliation Departments of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan

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• Yoshihiro Inoue,

  Roles Data curation

  Affiliation Departments of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan

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• Mitsuhiro Asakuma,

  Roles Data curation

  Affiliation Departments of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan

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• Hiroshi Haeno,

  Roles Writing – original draft

  Affiliation Mathematical Biology Laboratory, Department of Biology, Faculty of Sciences, Kyushu University, Fukuoka, Japan

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• Chung Yin Kong,

  Roles Writing – original draft

  Affiliation Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, United States of America

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• Kazuhisa Uchiyama,

  Roles Data curation

  Affiliation Departments of General and Gastroenterological Surgery, Osaka Medical College Hospital, Osaka, Japan

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• Mithat Gonen,

  Roles Formal analysis

  Affiliation Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

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• Chin Hur,

  Roles Data curation, Writing – original draft

  Affiliation Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, United States of America

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• Franziska Michor

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: michor@jimmy.harvard.edu

  Affiliations Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States of America, Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States of America, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, United States of America, Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, United States of America, The Broad Institute of Harvard and MIT, Cambridge, MA, United States of America

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