MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Simon T. Christensen; Sara E. Johansson; Aneta Radziwon-Balicka; Karin Warfvinge; Kristian A. Haanes; Lars Edvinsson

doi:10.1371/journal.pone.0215398

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Peer-reviewed

Research Article

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Simon T. Christensen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark

http://orcid.org/0000-0001-5754-1068

⨯
Sara E. Johansson,

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark
⨯
Aneta Radziwon-Balicka,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark
⨯
Karin Warfvinge,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliations Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark, Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
⨯
Kristian A. Haanes ,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: kristian.agmund.haanes@regionh.dk

Affiliation Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark

http://orcid.org/0000-0001-5182-8957

⨯
Lars Edvinsson

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Clinical Experimental Research, Copenhagen University Hospital, Rigshospitalet-Glostrup, Denmark, Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Lund, Sweden
⨯

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats

Simon T. Christensen,
Sara E. Johansson,
Aneta Radziwon-Balicka,
Karin Warfvinge,
Kristian A. Haanes,
Lars Edvinsson

Published: April 12, 2019
https://doi.org/10.1371/journal.pone.0215398

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Protein expression
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Cerebral arteries
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Muscle contraction
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