Placental P-glycoprotein inhibition enhances susceptibility to Di-(2-ethylhexyl)-phthalate induced cardiac malformations in mice: A possibly promising target for congenital heart defects prevention

• Changqing Tang ,

  Contributed equally to this work with: Changqing Tang, Chunyan Luo

  Roles Data curation, Formal analysis, Writing – original draft

  Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, West China Medical School of Sichuan University, Chengdu, Sichuan, China

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• Chunyan Luo ,

  Contributed equally to this work with: Changqing Tang, Chunyan Luo

  Roles Investigation, Writing – original draft

  Affiliation Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yimin Hua,

  Roles Conceptualization, Funding acquisition

  Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, The Cardiac development and early intervention unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Sichuan, China, Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Kaiyu Zhou,

  Roles Conceptualization

  Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, The Cardiac development and early intervention unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Sichuan, China, Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Hongyu Duan,

  Roles Investigation

  Affiliation Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Fan Ma,

  Roles Investigation

  Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, West China Medical School of Sichuan University, Chengdu, Sichuan, China

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• Yi Zhang,

  Roles Data curation, Formal analysis

  Affiliations The Cardiac development and early intervention unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Sichuan, China, Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Yifei Li,

  Roles Investigation

  Affiliation Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

  http://orcid.org/0000-0002-3096-4287

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• Dajian Qiu,

  Roles Investigation

  Affiliation The Cardiac development and early intervention unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

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• Chuan Wang

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – review & editing

  * E-mail: 805101396@qq.com

  Affiliations Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China, The Cardiac development and early intervention unit, West China Institute of Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

  http://orcid.org/0000-0001-5165-8273

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