Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia

• Kei Nishizawa ,

  Contributed equally to this work with: Kei Nishizawa, Noriaki Yoda

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft

  Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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• Noriaki Yoda ,

  Contributed equally to this work with: Kei Nishizawa, Noriaki Yoda

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, Department of Drug Metabolism and Pharmacokinetics, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., Tokushima, Japan

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• Fumi Morokado,

  Roles Investigation

  Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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• Hisakazu Komori,

  Roles Writing – review & editing

  Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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• Takeo Nakanishi,

  Roles Supervision, Writing – review & editing

  Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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• Ikumi Tamai

  Roles Conceptualization, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: tamai@p.kanazawa-u.ac.jp

  Affiliation Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

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