Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

Christina Schindler; Andie Collinson; Carl Matthews; Amy Pointon; Lesley Jenkinson; Ralph R. Minter; Tristan J. Vaughan; Natalie J. Tigue

doi:10.1371/journal.pone.0214545

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Open Access

Peer-reviewed

Research Article

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

Christina Schindler,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom

http://orcid.org/0000-0003-4427-5762

⨯
Andie Collinson,

Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯
Carl Matthews,

Roles Investigation, Methodology

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯
Amy Pointon,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Mechanistic Safety and ADME Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom
⨯
Lesley Jenkinson,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯
Ralph R. Minter,

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯
Tristan J. Vaughan,

Roles Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯
Natalie J. Tigue

Roles Conceptualization, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: tiguen@medimmune.com

Affiliation Department of Antibody Discovery and Protein Engineering, MedImmune Ltd., Cambridge, United Kingdom
⨯

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

Christina Schindler,
Andie Collinson,
Carl Matthews,
Amy Pointon,
Lesley Jenkinson,
Ralph R. Minter,
Tristan J. Vaughan,
Natalie J. Tigue

Published: March 29, 2019
https://doi.org/10.1371/journal.pone.0214545

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