Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes

Cristina Vazquez-Mateo; Justin Collins; Sarah J. Goldberg; Maxx Lawson; Jaileene Hernandez-Escalante; Hans Dooms

doi:10.1371/journal.pone.0214379

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Peer-reviewed

Research Article

Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes

Cristina Vazquez-Mateo,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Justin Collins,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Sarah J. Goldberg,

Roles Data curation, Formal analysis, Investigation

Affiliation Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Maxx Lawson,

Roles Data curation, Investigation

Affiliation Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-0772-6117

⨯
Jaileene Hernandez-Escalante,

Roles Data curation, Formal analysis, Investigation

Affiliations Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Hans Dooms

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hdooms@bu.edu

Affiliations Arthritis Center, Rheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, United States of America

http://orcid.org/0000-0001-7964-0876

⨯

Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes

Cristina Vazquez-Mateo,
Justin Collins,
Sarah J. Goldberg,
Maxx Lawson,
Jaileene Hernandez-Escalante,
Hans Dooms

Published: March 25, 2019
https://doi.org/10.1371/journal.pone.0214379

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