A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis

• Michael Boehm,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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• Eva Nora Bukosza,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Institute of Pathophysiology, Semmelweis University Budapest, Budapest, Hungary

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• Nicole Huttary,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria

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• Rebecca Herzog,

  Roles Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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• Christoph Aufricht,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliation Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

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• Klaus Kratochwill ,

  Contributed equally to this work with: Klaus Kratochwill, Christoph A. Gebeshuber

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: klaus.kratochwill@meduniwien.ac.at (KK); c.gebeshuber@epsilon3.at (CAG)

  Affiliations Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria, Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria

  http://orcid.org/0000-0003-0803-614X

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• Christoph A. Gebeshuber

  Contributed equally to this work with: Klaus Kratochwill, Christoph A. Gebeshuber

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: klaus.kratochwill@meduniwien.ac.at (KK); c.gebeshuber@epsilon3.at (CAG)

  Affiliation Epsilon 3 Gmbh, Vienna, Austria

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