Mesothelin and TGF-α predict pancreatic cancer cell sensitivity to EGFR inhibitors and effective combination treatment with trametinib

Ethan Poteet; Dongliang Liu; Zhengdong Liang; George Van Buren; Changyi Chen; Qizhi Yao

doi:10.1371/journal.pone.0213294

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Open Access

Peer-reviewed

Research Article

Mesothelin and TGF-α predict pancreatic cancer cell sensitivity to EGFR inhibitors and effective combination treatment with trametinib

Ethan Poteet,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Dongliang Liu,

Roles Investigation, Methodology, Validation, Visualization

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Zhengdong Liang,

Roles Investigation, Methodology, Validation, Visualization

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America
⨯
George Van Buren,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America

http://orcid.org/0000-0001-7637-3717

⨯
Changyi Chen,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Qizhi Yao

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: qizhiyao@bcm.edu

Affiliations Michael E. DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, United States of America, Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas, United States of America

http://orcid.org/0000-0002-2267-0588

⨯

Mesothelin and TGF-α predict pancreatic cancer cell sensitivity to EGFR inhibitors and effective combination treatment with trametinib

Ethan Poteet,
Dongliang Liu,
Zhengdong Liang,
George Van Buren,
Changyi Chen,
Qizhi Yao

Published: March 28, 2019
https://doi.org/10.1371/journal.pone.0213294

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MTT assay
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