Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

Kaori Ishikawa; Kohei Kobayashi; Akihito Yamada; Moe Umehara; Toshihiko Oka; Kazuto Nakada

doi:10.1371/journal.pone.0213283

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Open Access

Peer-reviewed

Research Article

Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

Kaori Ishikawa ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: k_ishikawa@biol.tsukuba.ac.jp (KI); knakada@biol.tsukuba.ac.jp (KN)

Affiliations Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan

http://orcid.org/0000-0001-9895-5996

⨯
Kohei Kobayashi,

Roles Investigation

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
⨯
Akihito Yamada,

Roles Investigation

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
⨯
Moe Umehara,

Roles Investigation

Affiliation Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
⨯
Toshihiko Oka,

Roles Supervision, Writing – review & editing

Affiliation Department of Life Science, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo, Japan
⨯
Kazuto Nakada

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: k_ishikawa@biol.tsukuba.ac.jp (KI); knakada@biol.tsukuba.ac.jp (KN)

Affiliations Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
⨯

Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells

Kaori Ishikawa,
Kohei Kobayashi,
Akihito Yamada,
Moe Umehara,
Toshihiko Oka,
Kazuto Nakada

Published: March 4, 2019
https://doi.org/10.1371/journal.pone.0213283

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Mitochondrial DNA
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Mouse models
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Mitochondria
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Insertion mutation
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Substitution mutation
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Mutation detection
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Mutation
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